Endocrine Abstracts

Introduction: Presentation of pituitary tumours can be variable.If is a functioning pituitary tumour the clinical manifestation will be that of excessive hormone secreted, and if is a non functioning pituitary tumour, the presentation will be that of target endocrine organ insufficiency.Bradycardia/complete heart block may be a non specific presentation of non functioning pituitary tumours.Cas...

Introduction: Presentation of pituitary tumours can be variable.If is a functioning pituitary tumour the clinical manifestation will be that of excessive hormone secreted, and if is a non functioning pituitary tumour, the presentation will be that of target endocrine organ insufficiency.Bradycardia/complete heart block may be a non specific presentation of non functioning pituitary tumours.Cas...

Background: Primary hyperparathyroidism during pregnancy is rare, and may present with symptoms non-specific to hypercalcaemia.Case: A 35 years old 12/40 weeks pregnant lady presented to accident and emergency department with 6 weeks history of nausea and vomiting. On admission she felt anxious with ongoing nausea and numbness all over the body. She was a mother 2-year-old with no significant past medical history. Her medication on admission were; folic ...

Background: The causes of symptomatic bradycardia/complete are multifactorial. Bradycardia/complete heart block may be drug induced, electrolyte imbalance, ischaemic heart disease, or thyroid dysfunction. Hypothyroidism and electrolyte disturbances are reversible.Objectives/aims: To dentify/find out whether thyroid function test where performed in patients presenting with bradycardia/CHB in keeping with good practice before insertion of permanent pace ma...

Background: Lithium remains a first-line treatment for bipolar affective disorder and acute maniac states.Lithium therapy is associated with a variety of side effects including thyroid dysfunction and hypercalcaemia. Hypercalcaemia and more rarely biochemical picture resembling primary hyperparathyroidism or familial hypocalciuric hypercalcaemia may develop. Recognition of this side effect is of vital importance as an increasing number of patients with b...

Introduction: Pituitary apoplexy is essentially bleeding into a necrotic area of the pituitary tumour, which has presumably outgrown its blood supply and caused infarction. Usually this is a haemorrhagic infarction but rarely a non-haemorrhagic infarction can cause marked pituitary swelling and presents as pituitary apoplexy. Our case represents a typical case of pituitary apoplexy with rapid evolving neurological deficit due to pituitary necrosis rather than haemorrhage.<...

Background: Familial dysalbuminaemic hyperthyroxinaemia (FDH) is an interesting autosomal dominant condition that is associated with euthyroid hyperthyroxinaemia, whereby patients remain euthyroid but laboratory value will show high free thyroxine (fT4) level. It is caused by mutations in ALB (albumin) gene that increase affinity of albumin for thyroxine (T4). The usual thyroid assay will show a spuriously high level of thyroxine. This interferen...

Introduction: Amiodarone is a well-established class III antiarrhythmic drug used in the treatment of arrhythmias and atrial fibrillation.Case report: HistoryA 68 year old gentleman who has background history of persistent Atrial fibrillation, dilated cardiomyopathy, took digoxin 125 mg, bisoprolol 2.5 mg and warfarin 2 mg, simvastatin 40 mg, Ramipril 10 mg. Digoxin was discontinued due to the nocturnal pauses, bradycardia on 24 ho...

Aims: To present the case of a 69-year-old female patient who was diagnosed with acromegaly two years following the initial onset of facial and acral symptoms, having already developed colonic hyperplastic polyps, one of the complications associated with acromegaly, one year prior to diagnosis.Material: Case report and literature review.Method: Acromegaly was diagnosed based on clinical suspicion, raised IGF-1 level, absence of GH ...

Background: Carney complex is rare multiple endocrine neoplasia syndrome affecting adrenal, pituitary and thyroid glands. It’s associated with other non-endocrine tumours such as cardiac, skin, mucosal or breast myxomas, testicular tumours, melanotic shwanomas and abnormal pigmentation (spotty skin pigmentation (freckles).Case: We present the case of a 54 year old lady, who was referred for echocardiography in December 2014 following an episode of p...